St. Luke's Hospital

St. Luke's COVID-19 Vaccine Clinic

St. Luke's Hospital's COVID-19 Vaccine Clinic welcomes and thanks you for doing your part to help keep our community healthy.

Updated: September 1, 2021

Our vaccine clinic is currently administering first, second and third (booster) doses of the Comirnaty (prior name was Pfizer-BioNTech) COVID-19 Vaccine to individuals who are eligible based on state guidelines and have pre-registered for a vaccination appointment.
Please note that a pre-registration form must be completed for each person requesting an appointment at St. Luke's Vaccine Clinic. Our vaccine clinic is unable to accommodate walk-in requests.

First or Second Dose:

The U.S. Food and Drug Administration (FDA) has granted full approval for COMIRNATY/Pfizer BioNTech's COVID-19 Vaccine for people 16 years of age and older. For children 12 to 15 years of age, the vaccine can be administered under an Emergency Use Authorization. The second dose of the vaccine is given at least 21 days after the first dose.

Third (Booster) Dose: Currently offered only for immunocompromised patients

A booster (third dose) of the Comirnaty COVID-19 Vaccine is now available under Emergency Use Authorization for certain immunocompromised individuals 16 years of age and older and can be received as soon as 28 days after the second dose. Individuals seeking a third (booster) dose will need to have received the Pfizer vaccine for their first two doses of protection and are asked to attest to being considered moderately or severely immunosuppressed because of one or more of the following conditions, treatments or diagnoses:
  • Immune compromised due to undergone solid organ transplantation and taking immune suppressing medications
  • Immune compromised due to active treatment for solid tumor and hematologic malignancies
  • Immune compromised due to receipt of CAR-T cell or hematopoietic stem cell transplant (within 2 years of transplantation or taking immunosuppression therapy)
  • Moderate to severe primary immunodeficiency (e.g., DiGeorge, Wiskott- Aldrich Syndromes)
  • Immune compromised due to Advanced or untreated HIV infection
  • Immune compromised due to "Active treatment with high-dose corticosteroids or other drugs that may suppress immune response: high-dose corticosteroids (i.e., ? 20 mg prednisone or equivalent per day), alkylating agents, antimetabolites, transplant related immunosuppressive drugs, cancer chemotherapeutic agents classified as severely immunosuppressive, tumor-necrosis (TNF) blocker or other biologic agents that are immunosuppressive or immunomodulatory"
Appointment Scheduling:

Vaccine doses are administered by appointment only at St. Luke's Vaccine Clinic on a first come, first served basis to individuals who have pre-registered.

St. Luke's Vaccine Clinic is located on our Chesterfield hospital campus in the Institute for Health Education, which is on the second floor (lower-level atrium area) of the North Medical Office Building (222 S. Woods Mill Road). Parking is available in the North/South parking garage or on surface lots adjacent to the medical office building.

Note: Please bring a photo ID, your COVID Vaccine Card and your health insurance card (if you have one) to your appointment. The vaccine is being provided to St. Luke's Hospital free of charge; however, we have been given guidance to bill insurance for the administration of the vaccine. The administration of the vaccine is covered by all payors with no out-of-pocket due from the patients.

Please be sure to wear comfortable clothing that will allow the St. Luke's healthcare professional to access your shoulder for the vaccination.

Social distancing and masks will be required for all participants.

You should not register to receive the COVID-19 vaccine if:
  • You have had passive antibody therapy such as convalescent plasma or monoclonal antibodies until 90 days have passed from completion of said therapy.
  • You have experienced a serious reaction to a prior dose of SARS-CoV-2 vaccine or any of its components.
  • You have been confirmed positive for COVID-19 within the past 10 days or been exposed to someone who has been diagnosed as a confirmed positive within the last 10 days.
If you are pregnant or have concerns about fertility, you should discuss with your OB/GYN prior to registering for the vaccine.

Questions? Contact St. Luke's Hospital via Email:

If you need assistance in scheduling your appointment, please call our COVID-19 Vaccine Scheduling Help Desk at (636) 685-7878.


For the most up-to-date information regarding the vaccine, visit the Missouri Department of Health and Senior Services COVID-19 vaccine website or the Centers for Disease Control and Prevention (CDC) Website:


St. Luke's is here for you! Routine checkups and screenings are essential to staying healthy. Now more than ever, it is important to maintain your healthcare appointments and screenings, especially if you are high risk or have chronic health conditions. St. Luke's hospitals, Urgent Care Centers and physician offices are open, safe and ready to provide you with world-class care. So, don't delay your healthcare. Please call your St. Luke's physician today or call 314-205-6060 for our physician referral services. For additional information, visit