St. Luke's Hospital

St. Luke's COVID-19 Vaccine Clinic

St. Luke's Hospital's COVID-19 Vaccine Clinic welcomes and thanks you for doing your part to help keep our community healthy.

Updated: January 17, 2022

St. Luke's COVID-19 Vaccine Clinic is currently administering the Comirnaty (prior name was Pfizer-BioNTech) COVID-19 Vaccine to individuals who are eligible based on the State of Missouri's guidelines and have pre-registered for a vaccination appointment.

If you are interested in COVID-19 vaccinations for ages 12 and older,
please read below.
Please note that a pre-registration form must be completed for each person requesting an appointment at St. Luke's Vaccine Clinic. Our vaccine clinic is unable to accommodate walk-in requests.

Our vaccine clinic is unable to provide booster vaccine doses to individuals who did not receive the Pfizer Comirnaty COVID-19 Vaccine for their primary dose series.

First or Second Dose:

The U.S. Food and Drug Administration (FDA) has granted full approval for the Pfizer Comirnaty COVID-19 Vaccine for people 16 years of age and older. For children 5 to 15 years of age, the vaccine can be administered under an Emergency Use Authorization. The second dose of the vaccine is given at least 21 days after the first dose.

Third (Booster) Dose:

The FDA has amended the emergency use authorization for the Pfizer Comirnaty COVID-19 Vaccine to allow for the use of a single booster dose for people ages 12 and older at least five months after the initial two-dose vaccination series, based upon guidelines from the Centers for Disease Control and Prevention (CDC).

Visit or for more information.

Appointment Scheduling:

Vaccine doses are administered by appointment only at St. Luke's Vaccine Clinic to individuals who meet state guidelines as stated above and have pre-registered. Our vaccine clinic is unable to accommodate walk-in requests.

St. Luke's Vaccine Clinic is located on our Chesterfield hospital campus in the Institute for Health Education, which is on the second floor (lower-level atrium area) of the North Medical Office Building (222 S. Woods Mill Road). Parking is available in the North/South parking garage or on surface lots adjacent to the medical office building.

Note: Please bring a photo ID, your COVID Vaccine Card and your health insurance card (if you have one) to your appointment. The vaccine is being provided to St. Luke's Hospital free of charge; however, we have been given guidance to bill insurance for the administration of the vaccine. The administration of the vaccine is covered by all payors with no out-of-pocket due from the patients.

Please be sure to wear comfortable clothing that will allow the St. Luke's healthcare professional to access your shoulder for the vaccination.

Social distancing and masks will be required for all participants.

You should not register to receive the COVID-19 vaccine if:
  • You have had passive antibody therapy such as convalescent plasma or monoclonal antibodies until 90 days have passed from completion of said therapy.
  • You have experienced a serious reaction to a prior dose of SARS-CoV-2 vaccine or any of its components.
  • You have been confirmed positive for COVID-19 within the past 10 days or been exposed to someone who has been diagnosed as a confirmed positive within the last 10 days.
If you are pregnant or have concerns about fertility, you should discuss with your OB/GYN prior to registering for the vaccine.

Questions? Contact St. Luke's Hospital via Email:

If you need assistance in scheduling your appointment, please call our COVID-19 Vaccine Scheduling Help Desk at (636) 685-7878.


For the most up-to-date information regarding the vaccine, visit the Missouri Department of Health and Senior Services COVID-19 vaccine website or the Centers for Disease Control and Prevention (CDC) Website:


St. Luke's is here for you! Routine checkups and screenings are essential to staying healthy. Now more than ever, it is important to maintain your healthcare appointments and screenings, especially if you are high risk or have chronic health conditions. St. Luke's hospitals, Urgent Care Centers and physician offices are open, safe and ready to provide you with world-class care. So, don't delay your healthcare. Please call your St. Luke's physician today or call 314-205-6060 for our physician referral services. For additional information, visit